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Jardiance vs Januvia: Understanding the Differences

When it comes to managing type 2 diabetes, there are various treatment options available. Two commonly prescribed medications are Jardiance vs Januvia. Both are used to help control blood sugar levels in people with type 2 diabetes, but they work in different ways and have some key differences. In this article, we’ll explore these differences to help you understand which medication may be more suitable for your needs.

What Is Jardiance?

Jardiance is the brand name for the medication empagliflozin. It belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors. Jardiance works by helping the kidneys remove excess glucose from the bloodstream through urine. This reduces the amount of glucose in the blood, helping to lower blood sugar levels.

What Is Januvia?

Januvia is the brand name for the medication sitagliptin. It falls under the category of dipeptidyl peptidase-4 (DPP-4) inhibitors. Januvia works by increasing the levels of certain natural substances called incretins in the body. These incretins help control blood sugar by stimulating the release of insulin and reducing the amount of glucose produced by the liver.

Key Differences Between Jardiance and Januvia

Now that we understand how each medication works, let’s compare Jardiance and Januvia based on some important factors:

Mechanism of Action:

  • Jardiance: Works by promoting the excretion of excess glucose through urine.
  • Januvia: Operates by enhancing the effects of incretins, which stimulate insulin release and reduce liver glucose production.

Mode of Administration:

  • Jardiance: Typically taken as a once-daily oral tablet.
  • Januvia: Also taken as a once-daily oral tablet.


Both Jardiance and Januvia are effective at lowering blood sugar levels. However, individual responses may vary, and the choice between the two may depend on factors such as the patient’s specific needs and any existing medical conditions.

Side Effects:

Both medications may have side effects, including:

  • Jardiance: Common side effects may include urinary tract infections, increased urination, and low blood pressure.
  • Januvia: Common side effects may include upper respiratory tract infections, headaches, and stomach discomfort.

It’s essential to discuss potential side effects with your healthcare provider to determine which medication is the best fit for you.


The cost of medications can vary depending on your insurance coverage and location. It’s a good idea to check with your insurance provider and compare prices at local pharmacies to determine the most cost-effective option for you.

Additional Considerations:

  • Jardiance: Some studies suggest that Jardiance may have cardiovascular benefits beyond blood sugar control, such as reducing the risk of heart-related events.
  • Januvia: May be a suitable choice for people who prefer a medication that stimulates insulin release without causing weight gain.

Consult Your Healthcare Provider

Ultimately, the choice between Jardiance vs Januvia should be made in consultation with your healthcare provider. They will consider your individual medical history, current health status, and treatment goals to determine which medication is most appropriate for managing your type 2 diabetes.

It’s crucial to follow your healthcare provider’s recommendations and monitor your blood sugar levels regularly while taking either medication. Additionally, maintaining a healthy lifestyle with a balanced diet and regular exercise is essential in managing type 2 diabetes effectively.


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